Relevant beyond the Roman period: approaches to the investigation, analysis and dissemination of archaeological investigations of the rural settlements and landscapes of Roman Britain

Archaeology has been firmly embedded in the British planning systems for over a quarter of century, and development-led fieldwork is now by far the largest source of new information available to researchers. Custom and practice in the way that such work is conducted has evolved over this time, yet methodological innovation has been surprisingly limited. Using the data gathered in a major survey of the rural settlement of Roman Britain, this paper explores some themes in the way that commercial work is undertaken and seeks to open up a long-overdue debate about professional practice in a development-led context

Oxytocin Receptor Gene (OXTR) and Father Support Interact to Predict Depressive Symptoms Postpartum

Postpartum depression (PPD) is a debilitating mental illness affecting approximately 13% of mothers after birth. Both genetic and psychosocial factors contribute to PPD risk, but very little is known about how these factors interact. We tested whether the rs53576 polymorphism in the oxytocin receptor (OXTR) gene accounts for variation in the impact of low social support as a risk factor for depression among mothers during the perinatal period. New mothers (N = 220) provided saliva or blood DNA samples and completed surveys assessing PPD symptoms and perceived social support. In a significant interaction, social support from the baby’s father predicted PPD symptoms to a greater extent among mothers with the GG compared to AG and AA genotypes. These results add to converging evidence that variation in OXTR rs53576 moderates the impact of the social environment on PPD

Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease.

Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood. Using the acute macaque model of EVD, we hypothesized EBOV would infect the reproductive tissues and sought to localize the infection in these tissues using immunohistochemistry and transmission electron microscopy. In four female and eight male macaques that succumbed to EVD between 6 and 9 days after EBOV challenge, we demonstrate widespread EBOV infection of the interstitial tissues and endothelium in the ovary, uterus, testis, seminal vesicle, epididymis, and prostate gland, with minimal associated tissue immune response or organ pathology. Given the widespread involvement of EBOV in the reproductive tracts of both male and female macaques, it is reasonable to surmise that our understanding of the mechanisms underlying sexual transmission of EVD and persistence of EBOV in immune-privileged sites would be facilitated by the development of a nonhuman primate model in which the macaques survived past the acute stage into convalescence

The Design Space of Generative Models

Card et al.'s classic paper "The Design Space of Input Devices" established the value of design spaces as a tool for HCI analysis and invention. We posit that developing design spaces for emerging pre-trained, generative AI models is necessary for supporting their integration into human-centered systems and practices. We explore what it means to develop an AI model design space by proposing two design spaces relating to generative AI models: the first considers how HCI can impact generative models (i.e., interfaces for models) and the second considers how generative models can impact HCI (i.e., models as an HCI prototyping material)

Importance, elicitation order, and expectancy x value

Considerable confusion surrounds the role of importance in multiattribute attitude models. The present study tests a theoretical proposition as to how attribute importance is manifested in the expectancy-value formulation. Though not unequivocal, the results suggest that order of elicitation may be more valid than structured ratings as an indicant of attribute importance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23880/1/0000119.pd

Retinal Detachment with Vitreous Hemorrhage Causing Acute Angle Closure Glaucoma

A 90-year-old female with past medical history of trigeminal neuralgia presented with a four-day history of a left-sided headache, nausea, vomiting, and vision loss in her left eye and one month of intermittent flashes of light in her left eye. Her left eye was diffusely injected with a cloudy cornea and fixed, mid-dilated, and non-reactive pupil. The vision in her, right eye was 20/200 with an intraocular pressure (IOP) of 16 mm Hg; her left eye was no light perception (NLP) with an IOP of 56 mm Hg. She was started on dorzolamide, brimonidine, and latanoprost eye drops. A bedside ultrasound performed by an emergency medicine physician demonstrated evidence of vitreous hemorrhage and concern for retinal detachment. Slit lamp examination performed by ophthalmologist demonstrated the left anterior chamber to be flat with a bulging iris and detached retina. Consequently, the patient was diagnosed with acute angle closure glaucoma secondary to increasing posterior chamber pressures. Given concern for altered mental status, the patient received a CT head in association with an inpatient MRI for headache refractory to home carbamazepine dosing regimen. Both imaging modalities corroborated the ultrasound\u27s findings. In addition to the IOP-lowering medications, atropine, traditionally contraindicated in primary acute angle closure glaucoma, was added. Given her age, length of symptoms, and lack of light perception at presentation, her vision was deemed unsalvageable. Her pain was controlled with oral opioids and she was discharged with outpatient ophthalmology follow-up. At time of discharge, the IOP in her left eye was 49 mm Hg.https://scholarlycommons.henryford.com/merf2020caserpt/1007/thumbnail.jp

On the motivating impact of price and online recommendations at the point of online purchase

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 ElsevierDo online recommendations have the same motivating impact as price at the point of online purchase? The results (n = 268) of an conjoint study show that: (1) when the price is low or high relatively to market price, it has the strongest impact (positive and negative) on the likelihood of an online purchase of an mp3 player, (2) when the price is average to market price, online recommendation and price are equal in their impact at the point of online purchase, and, (3) the relative impact from price increases when online shopping frequencies increases. The implications these results give are that online retailers should be aware that online recommendations are not as influential as a good offer when consumers purchase electronics online. However, other customer recommendations have a stronger impact on novice online shoppers than towards those consumers that shop more frequently online

Human Performance Contributions to Safety in Commercial Aviation

In the commercial aviation domain, large volumes of data are collected and analyzed on the failures and errors that result in infrequent incidents and accidents, but in the absence of data on behaviors that contribute to routine successful outcomes, safety management and system design decisions are based on a small sample of non- representative safety data. Analysis of aviation accident data suggests that human error is implicated in up to 80% of accidents, which has been used to justify future visions for aviation in which the roles of human operators are greatly diminished or eliminated in the interest of creating a safer aviation system. However, failure to fully consider the human contributions to successful system performance in civil aviation represents a significant and largely unrecognized risk when making policy decisions about human roles and responsibilities. Opportunities exist to leverage the vast amount of data that has already been collected, or could be easily obtained, to increase our understanding of human contributions to things going right in commercial aviation. The principal focus of this assessment was to identify current gaps and explore methods for identifying human success data generated by the aviation system, from personnel and within the supporting infrastructure

An Approach to Quantify Workload in a System of Agents

The role of humans in aviation and other domains continues to shift from manual control to automation monitoring. Studies have found that humans are often poorly suited for monitoring roles, and workload can easily spike in off-nominal situations. Current workload measurement tools, like NASA TLX, use human operators to assess their own workload after using a prototype system. Such measures are used late in the design process and can result in ex- pensive alterations when problems are discovered. Our goal in this work is to provide a quantitative workload measure for use early in the design process. We leverage research in human cognition to de ne metrics that can measure workload on belief-desire-intentions based multi-agent systems. These measures can alert designers to potential workload issues early in design. We demonstrate the utility of our approach by characterizing quantitative differences in the workload for a single pilot operations model compared to a traditional two pilot model